Burn wound healing is a series of complex processes which are subject to intensive investigations to improve the outcomes, the healing time and the quality of the scar. Severe Burn injuries have always proven to have devastating effects on the affected patients. Stem cells helps in superior healing of the wounds and helps in decreasing the inflammation levels with less scar progression and fibrosis.
In the case of wound healing, different types of stem cells have been used for different types of wounds.Burnwounds have proven to be capable of having a devastating effect both functionally and cosmetically, necessitating the search for a better and more efficient cure. Stem cells are undifferentiated pluripotential cells that can regenerate to any other types of cells, including new stem cells identical to mother cells. Stem cells can be of embryonal origin or adult origin, depending on the type of tissue they are derived from. Embryonal stem cells are derived from either embryonal tissue or from germ cells in adults. And the adult stem cells are derived from adult tissues of different organs, especially those with a high turnover rate such as intestines and bone marrow.
Stem cells have been very effective and promising in the healing of wounds. However, the methods of using the stem cells in burn wound healing are different like topical application, local injection, intravenous or systemic injection, and dermal or carrier application. Several studies have shown the efficacy of stem cells in promoting faster and superior wound healing. Stem cell therapy for wounds healinghas proven more efficient by their proliferative effect on keratinocytes. Moreover, this effect of stem cells was found to be mediated by keratinocyte growth factor-1 (KGF-1) and platelet derived growth factor-BB (PDGF-BB). Additionally, stem cells are notintegrating permanently in the tissue, thus, suggesting that their effect is due to released factors and not by direct interaction. Additionally, bone marrow derived mesenchymal stem cells have also been used in wound healing.
The stem cells play a role in promoting wound healing in burns.Concerning the physiology stem cells enhance the process of burn wound healing. Hencean increased levels of bone marrow produces endothelial progenitor cells in burn patients. These levels are proportional to the extent of the burn. Focusing on the role of cytokines in burn wound healing, amnion produces cellular cytokine solution. The amnion produces multipotent progenitor cells to harvest cytokines and apply them in burn wound healing. Cellular Cytokine solutionshows significant improvement in the epithelialization of the burn wounds and the appearance of hair growth compared to controls. Stem Cells have an active role in burn wound healing by producing bioactive peptides, such as thymosin 4 and others.
Mesenchymal stem cells stimulate the formation of a basket weave organization of collagen in bleomycin treated skin, like normal skin. Stem Cell treatment of the skin decreases markers of myofibroblasts and downregulated type I collagen, leading to a decrease in the fibrosis that could have occurred to the skin.The role of stem cells in decreasing bleomycin induced fibrosis may be extrapolated to decrease fibrosis in burn wounds and improve their healing with less scar formation. It induces leucine-rich repeat-containing G-protein-coupled receptors which are markers of adult epithelial stem cells both in skin and intestine.
The process of burn wound healing involves different types of growth factors, receptors, and cytokines. These factors are related to stem cell homing, differentiation, and proliferation therefore when applied to burn wounds, it leads to a better and faster healing process.
Therapeutic use of HBOT in burns is most often utilized for second and third degree burns cases. In third degree burns, the initial thermal injury occurs followed by circumferential, widening tissue loss which means that the surrounding tissue of the burn also becomes damaged because the blood vessels have been destroyed because of the burn. When the blood vessels are destroyed, downstream blood flow from the burn site is arrested, propagating further tissue death due to lack of oxygen.
HBOT given within the first 48 to 72 hours following thermal injury increases the oxygen saturation to the body by up to 12 times that of breathing air at sea level. This can mitigate ischemia reperfusion injury and the possibility of advanced tissue destruction beyond the initial area of thermal injury by supplying the body with added oxygen that, in turn, can bring the damaged area "back to life." This signals the body that the tissue is no longer a foreign invader and consequently, normal wound-healing processes can take place.
Beyond 72 hours, HBOT helps by continuing to promote new tissue growth, which encourages healing by aiding in the manufacturing of new blood vessels, which, in turn, make fibroblasts that are responsible for collagen production. In addition, HBOT reduces the body's inflammation which otherwise would slow down the healing process. Finally, HBOT also offers infection control, as oxygen is the white blood cell's weapon to kill bacteria.
Stem Cells decreases cell infiltration, wound contraction, fibrosis, scar progression, and inflammation of burn wounds. Moreover, it promotes faster burn wound healing and angiogenesis along with better granulation and the formation of hair follicles and sebaceous glands. Stem cells have proved to be efficient not only in skin burns but also in corneal chemical burns.With the advance of burn wound treatment with time, patient’s self-esteem the quality of life has been improving.
The hope is that the use of stem cells will open a new arena of possibilities to improve the wound healing in burn patients, allowing patients to have faster healing, better scars, and a higher quality of life. In brief, the use of stem cells in burn wound healing appears to be very promising. Additionally, stem cells involved in the burn wound healing along with their factors and signals constitute a very dynamic and promising effect on the burn wounds.
India have the most affordable places for Stem Cell treatment across the globe. We certainly understand that if you have chosen to travel overseas for Stem Cell treatment, then you are indeed looking for cost effectiveness. When you speak about the best, MedicoExperts is the name you can trust on. Modern technology, State of the art hospitals, experts, specialists, excellent infrastructure at par with international standards, no language barrier, personalized attention, safe surgery and seamless travel are some of our zeniths which magnetizes individuals worldwide to get their Stem Cell treatment in India done through us.
The patient must stay for 30 days, however in some cases 45 days of stay is recommended. The approximate cost of Stem Cell Treatment would range between USD 6500 to USD 10000 per cycle depending on current condition of the patient.Hyperbaric treatments average cost is between 50-90 USD per session, each of 60-90 minutes for 25-30 days daily.
We at MedicoExperts provide you evidence based, state of the art and affordable surgicaltreatment options for moderate to severe life-threatening obesity with no wait for patients who wish to take control of their health and life!
We completely understand patients with severe burn wounds, tend to have lower quality of life. The injury they suffer is not only physical but also psychological, affecting their jobs and relations with other people, especially their families.Stem Cell Treatment is a life changing decision andwhen you choose to get it miles away from your home, the decision can be overwhelming. Our dedicatedteam of MedicoExperts is there to help you at each step to get the best deal and make an informed decision.We assure you to be a personalized partner in your journey and make this journey for Stem Cell Therapy in Indiaa successful and memorable one for you!
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